Project Summary: Water and food security are major concerns in Egypt, the MENA-GCC region, and California due to limited irrigation water, high temperatures, and freshwater shortages. Controlled environment agriculture (CEA), such as greenhouses (GHs), improves crop yields but is highly energy-intensive. Current heating and cooling methods, including evaporative cooling and mechanical systems, have drawbacks like high water and energy consumption, inadequate shading, and limited use of renewable energy. These challenges significantly increase capital (CAPEX) and operational (OPEX) costs, making agriculture expensive. Egypt and California have abundant solar and wind energy, offering a sustainable solution to greenhouse inefficiencies while also generating power and producing water. This project focuses on developing an innovative renewable energy-driven aquaponic system integrated with desalination technology. It includes techno-economic modeling, detailed design, and pilot testing to enhance sustainability. Machine learning and artificial intelligence will optimize system performance and indoor climate control. The goal is to establish a water-energy-food-ecosystem (WEFE) nexus, particularly benefiting small remote coastal communities in Egypt, California, and the MENA-GCC region. The project aims to develop interconnected micro-complex subsystems, fostering a sustainable and green ecosystem. Findings will be shared with small and medium-sized industries (SMI/SME) to support commercialization pathways.